The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Milk thistle may help strengthen a persons immune response. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. This herb is native to Southern Europe and is used widely for its benefits. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. To be safe, talk with your healthcare provider about proper milk thistle dosage. Read our. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. It may not be safe for people with hormone-sensitive breast cancer. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. He has been in the digital media field for over eight years. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. Other studies looking at milk thistle for cirrhosis have found conflicting results. Milk thistle. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. However, there is a lack of . Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Agency for Healthcare Research and Quality (US); 2000. [Database subscription]. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Last medically reviewed on December 17, 2021. StatPearls Publishing; 2022. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. In one case, milk thistle had caused excessive sweating and weakness (14). Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). 2016;5147468. doi:10.1155/2016/5147468. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Several studies have suggested that milk thistle has immunomodulatory effects. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Milk thistle could play an essential role in supporting bone health. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. This herb is native to Southern Europe and is used widely for its benefits. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. We explore the potential health benefits of milk thistle below. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. People with diabetes should use caution. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Certain individuals might experience weakness with milk thistle. Olive Oil Vs. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. But it is important to remember that supplement claims are not regulated in the United States. Its seed might protect liver cells from toxic chemicals and drugs. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Milk thistle may not be safe for everyone. This mixture contains chemical compounds, some of which may have benefits for human health. Can Apoaequorin Really Improve Your Memory? Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Oxidative stress is a potential cause of Alzheimers disease. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Click here for additional information. Milk thistle comes in many forms, including tea. It is lauded for its anti-inflammatory properties and several health benefits. Does Milk Thistle Capsule interact with other medications? Learn more about the other negative effects of this herb and what research says about them. J Diabetes Res. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. 2014;97 Suppl 11:S31-S40. Properly discard this product when it is expired or no longer needed. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Highly clinically significant. It seems to help lower blood sugar. This publication is not copyrighted and is in the public domain. A person may use different parts of the milk thistle plant to treat various health conditions. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. This is not a complete list of side effects and others may occur. Take your next dose at the regular time. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. There are 4 drugs known to interact with The mention of any product, service, or therapy is not an endorsement by NCCIH. Phytother Res. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Possibly. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Effects of Silybum marianum (L.) Gaertn. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Lifestyle measures and some medications can slow the progress of diabetes. The FDA has not approved milk thistle to treat any health conditions. By Brittany Lubeck, RD Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Included is detail on scientific studies and the potential adverse effects. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Some people may be allergic to milk thistle. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Dosage: How Much Milk Thistle Should I Take? 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. The terms "milk thistle" and "silymarin" are often used interchangeably. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Milk thistle is native to the Mediterranean region. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Milk thistle may lower blood sugar levels in people with type 2 diabetes. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Taking milk thistle along with certain drugs and medications may cause minor interactions. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. It also seems to have antioxidant and anti-inflammatory effects. So, consult a doctor to understand about its long term usage. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. increased sweating. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Save the high-quality PDF version on your device now. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Adv Ther. Am J Gastroenterol. In:Drugs and Lactation Database (LactMed). Achufusi TGO, Patel RK. Milk thistle side effects (more detail) But the herb is also believed to be beneficial for other health issues. Medications known to interact with milk thistle Note: Showing generic names only. US residents can call their local poison control center at 1-800-222-1222. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. If you buy through links on this page, we may earn a small commission Heres our process. Milk thistle (PDQ) health professional version. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Follow all directions on the product package. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Talk to your pharmacist for more details. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Cymbalta side effects (more detail) Milk thistle grows in Europe but can also be found in the United States and South America. Olive Oil Vs. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X deficiency in among. 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