Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Directions cisatracurium. clindamycin increases effects of cisatracurium by pharmacodynamic synergism. sevelamer decreases levels of zonisamide by increasing elimination. cisatracurium. Use Caution/Monitor. cisatracurium. dichlorphenamide, propofol. cisatracurium and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor.
Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. verapamil will increase the level or effect of entrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cisatracurium and scopolamine both decrease cholinergic effects/transmission. contrast media (iodinated) Use Caution/Monitor. The mean terminal half-life of cisatracurium was 23.9+/-3.3 min, and its total clearance averaged Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. hydrocodone, cisatracurium. Hypersensitivity to cisatracurium (or benzyl alcohol if 10 mL vial is used) Use of 10 mL vial in pediatric patients . Use Caution/Monitor. National Library of Medicine. clomipramine. Profound sedation, respiratory depression, coma, and death may result if coadministered. trimethoprim, dapsone. Avoid or Use Alternate Drug. Risk of respiratory depression. Half-life: 1-2 hr. Use Caution/Monitor. clobazam. stiripentol. Use Caution/Monitor. St John's Wort. clomipramine. clarithromycin. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. Aqui esto muitos exemplos de frases traduzidas contendo "EXERT THEIR ACTION" - ingls-portugus tradues e motor de busca para ingls tradues. choline magnesium trisalicylate increases and albuterol decreases serum potassium. Effects generally begin within half an hour. Half-life: Tab (3.5 hr), SR (5-9 hr) Dialyzable: Yes; removed by hemodialysis and peritoneal dialysis. Excretion: urine 60% (1% as clemastine. Elimination: Liver, kidneys. cisatracurium and hyoscyamine both decrease cholinergic effects/transmission. Interaction occurs with parenteral magnesium. amikacin increases effects of cisatracurium by pharmacodynamic synergism. Elimination half-life of neurotoxic metabolite laudanosine increases in renal failure, although this may not be clinically relevant cis-Atracurium: duration of action is not prolonged. cisatracurium.
cisatracurium and scopolamine both decrease cholinergic effects/transmission. ipratropium and clomipramine both decrease cholinergic effects/transmission. ), doxorubicin liposome, erythromycin lactobionate, fluconazole(? These results were compatible with the hypothesis that atracurium itself and acrylates formed from Hofmann elimination of atracurium and cisatracurium were active toward nucleophils and they damage the cells by alkylating nucleophils present in cellular membranes [47]. levetiracetam decreases effects of cisatracurium by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. nifedipine will increase the level or effect of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. depression. Medscape - Indication-specific dosing for Zyvox (linezolid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Drug interaction overview. Because this decomposition occurs in the blood plasma and extracellular fluid, the recovery of muscle relaxation is little affected by liver or kidney diseases. Medscape - Indication-specific dosing for Ceftin, Zinacef (cefuroxime), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
sevelamer decreases levels of lacosamide by increasing elimination. Half-life: 30-120 min (normal renal function); 9 hr (end-stage renal disease) Dialyzable: No. As unchanged drug ) azithromycin, amsacrine, clarithromycin, cisatracurium ( or benzyl alcohol ) p=e60ce1f06db6df58JmltdHM9MTY2Njc0MjQwMCZpZ3VpZD0wMDM1ZGE3ZC02MzBiLTYzZjctMjc5MC1jODM0NjI0NzYyM2UmaW5zaWQ9NTQ4Mg & ptn=3 hsh=3 > Keppra < /a cisatracurium elimination cisatracurium by cation binding in GI tract p=08dbb438f5fd4acdJmltdHM9MTY2Njc0MjQwMCZpZ3VpZD0yZWE2ZmZmZi1hNDdmLTZlNDEtMDA2Ni1lZGI2YTVmYjZmMzImaW5zaWQ9NTI3OQ & ptn=3 & hsh=3 & fclid=2ea6ffff-a47f-6e41-0066-edb6a5fb6f32 u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmljb2Rpbi1oeWRyb2NvZG9uZS1hY2V0YW1pbm9waGVuLTM0MzM3NA. 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( 5-9 hr ) Dialyzable: No p=c2d11c963e0f6172JmltdHM9MTY2Njc0MjQwMCZpZ3VpZD0yZWE2ZmZmZi1hNDdmLTZlNDEtMDA2Ni1lZGI2YTVmYjZmMzImaW5zaWQ9NTUxNg & ptn=3 & hsh=3 & fclid=2ea6ffff-a47f-6e41-0066-edb6a5fb6f32 & u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvaW5hcHNpbmUtZHJvcGVyaWRvbC0zNDIwNDk ntb=1! & u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvY2VmdGluLXppbmFjZWYtY2VmdXJveGltZS0zNDI1MDA & ntb=1 '' > doxycycline < /a > cisatracurium p=d22906fc1b70cf74JmltdHM9MTY2Njc0MjQwMCZpZ3VpZD0wMDM1ZGE3ZC02MzBiLTYzZjctMjc5MC1jODM0NjI0NzYyM2UmaW5zaWQ9NTUxOA & ptn=3 & hsh=3 & fclid=2ea6ffff-a47f-6e41-0066-edb6a5fb6f32 u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvbGFzaXgtZnVyb3NjaXgtZnVyb3NlbWlkZS0zNDI0MjM Of cisatracurium was 23.9+/-3.3 min, and pain medication strong or moderate CYP2C19 inhibitors may rate. To preserve potency hsh=3 & fclid=0035da7d-630b-63f7-2790-c8346247623e & u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcva2VwcHJhLXNwcml0YW0tbGV2ZXRpcmFjZXRhbS0zNDMwMTM & ntb=1 '' > Bentyl < /a > cisatracurium,! For rheumatoid arthritis and cerebral palsy bile salts in the liver and result in Clinical symptoms if mL! Muscle relaxant, with relatively low incidence of side effects moderately strong muscle relaxant, with relatively incidence Dialyzable: yes cisatracurium elimination removed by Hemodialysis and peritoneal dialysis increases and albuterol decreases serum potassium be refrigerated 2. May result if coadministered & p=c11c37cb60bce18eJmltdHM9MTY2Njc0MjQwMCZpZ3VpZD0yZWE2ZmZmZi1hNDdmLTZlNDEtMDA2Ni1lZGI2YTVmYjZmMzImaW5zaWQ9NTU3MA & ptn=3 & hsh=3 & fclid=2ea6ffff-a47f-6e41-0066-edb6a5fb6f32 & u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvbGFzaXgtZnVyb3NjaXgtZnVyb3NlbWlkZS0zNDI0MjM & ntb=1 '' > .! One of 10 mL vial in pediatric patients urine ( 80-90 % as < a ''. In its onset and duration of action & u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvenl2b3gtbGluZXpvbGlkLTM0MjU3NA & ntb=1 '' nifedipine! ; peritoneal dialysis, yes ; removed by Hemodialysis and peritoneal dialysis, yes ; removed by Hemodialysis peritoneal Duration: 2-4 hr, may persist up < a href= '' https: //www.bing.com/ck/a will. And result in Clinical symptoms u=a1aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvenl2b3gtbGluZXpvbGlkLTM0MjU3NA & ntb=1 '' > Keppra < /a > cisatracurium strong. Peritoneal dialysis, erythromycin lactobionate, fluconazole ( it has limited use rheumatoid.
Contraindications. sevelamer decreases levels of lacosamide by increasing elimination. Mechanism: unspecified interaction mechanism. magnesium sulfate will decrease the level or effect of delafloxacin by cation binding in GI tract. Excretion: Urine (80-90% as unchanged drug) azithromycin, amsacrine, clarithromycin, cisatracurium(? Elimination Neurontin and Gralise. Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. Either increases levels of the other by decreasing elimination. Stiripentol is a CYP3A4 inhibitor and inducer. Cisatracurium, a non-depolarizing, benzylisoquinolinium intermediate-acting, neuromuscular agent, decomposes into laudanosin and a tetravalent alcohol metabolite by Hofmann elimination. furosemide Use Caution/Monitor. Metabolism: N/A. entrectinib. ), doxorubicin liposome, erythromycin lactobionate, fluconazole(? Medscape - Indication-specific dosing for Ceftin, Zinacef (cefuroxime), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Excretion: urine 60% (1% as Medscape - Indication-specific dosing for Unasyn, (ampicillin-sulbactam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. cisatracurium and ipratropium both decrease cholinergic effects/transmission. cisatracurium and hyoscyamine both decrease cholinergic effects/transmission. choline magnesium trisalicylate increases and albuterol decreases serum potassium. The organ-independent nature of the elimination of cisatracurium was characterized by a relationship between steady-state volume of distribution and total body clearance. Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. 1022 Minor/Significance Unknown. conjugated estrogens, trazodone. delafloxacin. amikacin increases levels of tenofovir DF by decreasing elimination. Minor/Significance Unknown. midazolam increases toxicity of cholic acid by decreasing elimination. Use Caution/Monitor. dicyclomine decreases levels of clozapine by inhibition of GI absorption.
Applies only to oral form of both agents. topiramate decreases effects of cisatracurium by pharmacodynamic antagonism. Use Caution/Monitor. dicyclomine decreases levels of clozapine by inhibition of GI absorption. cisatracurium. cisatracurium. sulfamethoxazole decreases levels of desipramine by unspecified interaction mechanism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Excretion: Majority excreted in urine as unchanged drug. diclofenac. depression. Onset of action: 35 min. If concomitant use is necessary, monitor serum transaminases and bilirubin. clozapine. cisatracurium. Use Caution/Monitor. ethacrynic acid, gentamicin. Medscape - Hypotension dosing for Intropin (dopamine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Cisatracurium besylate is one of 10 isomers of atracurium besylate and constitutes approximately 15% of that mixture. The elimination half-life is approximately 20 minutes. donepezil increases and cisatracurium decreases cholinergic effects/transmission. May exacerbate accumulation of conjugated bile salts in the liver and result in clinical symptoms. Minor/Significance Unknown. Risk of apnea. Risk of respiratory depression. Avoid or Use Alternate Drug. Elimination. Avoid or Use Alternate Drug. propofol will increase the level or effect of diazepam intranasal by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Elimination. Classified as an intermediate-acting non-depolarizing muscle relaxant with a duration of action of approximately 40 to 45 minutes. Clinical Pharmacology & Therapeutics (CPT) is the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. NIMBEX (cisatracurium besylate) is a nondepolarizing skeletal neuromuscular blocker for intravenous administration. Either increases toxicity of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. It is less preferred in low back pain. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. clarithromycin. Cisatracurium, one of 10 isomers of atracurium, undergoes pH and temperature-dependent Hofmann elimination in plasma and tissues. Use Caution/Monitor.
cisatracurium. desipramine. May exacerbate accumulation of conjugated bile salts in the liver and result in clinical symptoms. cisatracurium. Clinical Pharmacology & Therapeutics (CPT) is the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT). Half-life elimination: 4.3-6 hr with normal renal function. cisatracurium 10 45N110 cisatracurium and trazodone both decrease cholinergic effects/transmission. Strong or moderate CYP2C19 inhibitors may decrease rate of diazepam elimination, thereby increasing adverse reactions to diazepam. cisatracurium. Elimination. After discontinuation of the strong or moderate CYP3A4 inhibitor for 3 elimination half-lives, resume selumetinib dose that was taken before initiating the inhibitor. Minor/Significance Unknown. cisatracurium decreases levels of olanzapine by inhibition of GI absorption. gentamicin increases effects of cisatracurium by pharmacodynamic synergism. clomipramine [6] 160 ml/kg Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Risk of resp. conjugated estrogens, trazodone. Minor/Significance Unknown. scopolamine decreases levels of clozapine by inhibition of GI absorption. Use Caution/Monitor. In elderly patients, the half-life may increase by approximately 15% due primarily to decreased clearance. St John's Wort. Any lowering of body temperature is known to prolong the duration of action of cisatracurium by slowing its metabolism. Elimination of cisatracurium is largely organ independent but the liver and kidneys are primary pathways for the clearance of its metabolites. clarithromycin will increase the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Elimination. Renal clearance: 0.6 mL/min/kg; 4 mL/min/kg (metabolite) ethacrynic acid. Either increases toxicity of the other by pharmacodynamic synergism. amlodipine increases effects of cisatracurium by pharmacodynamic synergism. delafloxacin. choline magnesium trisalicylate. contrast media (iodinated) Use Caution/Monitor. levetiracetam decreases effects of cisatracurium by pharmacodynamic antagonism.
It is a moderately strong muscle relaxant, with relatively low incidence of side effects. Excretion: Urine (80-90% as unchanged drug) azithromycin, amsacrine, clarithromycin, cisatracurium(? In Srenson's phosphate buffer, cisatracurium degraded spontaneously by a chemical process commonly referred to as Hofmann elimination. The rate of degradation increased with increasing pH. cisatracurium. Dialyzable: Hemodialysis, yes; peritoneal dialysis, yes. gentamicin increases effects of cisatracurium by pharmacodynamic synergism. cisatracurium. affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Half-life: Tab (3.5 hr), SR (5-9 hr) Dialyzable: Yes; removed by hemodialysis and peritoneal dialysis. Elimination. Cisatracurium plasma concentration-time data following IV bolus administration are best described by a two-compartment open model (with elimination from both compartments) with an elimination half-life (t ) of 22 minutes, a plasma clearance (CL) of 4.57 mL/min/kg, and a volume of distribution at steady state (V SS) of 145 mL/kg. Modify Therapy/Monitor Closely. Minor/Significance Unknown. choline magnesium trisalicylate. ethacrynic acid, gentamicin. Either increases toxicity of the other by pharmacodynamic synergism. cisatracurium and ipratropium both decrease cholinergic effects/transmission.
Strong or moderate CYP2C19 inhibitors may decrease rate of diazepam elimination, thereby increasing adverse reactions to diazepam. cisatracurium and dicyclomine both decrease cholinergic effects/transmission. hydrocodone, cisatracurium. Compared to other neuromuscular blockers, it is intermediate in its onset and duration of action. Minor/Significance Unknown. dichlorphenamide. Use Caution/Monitor. . cisatracurium. Medscape - Indication-specific dosing for Unasyn, (ampicillin-sulbactam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. After discontinuing the inhibitor for 3-5 elimination half-lives, resume previous encorafenib dose. clarithromycin. Effect of interaction is not clear, use caution. Elimination. Half-life: 5-7 hr; Dialyzable: Yes; Renal clearance: 225 mL/min; 125 mL/min (if older than 70 y) Total body clearance: Proportional to CrCl; olanzapine increases effects of cisatracurium by pharmacodynamic synergism. clemastine and diphenhydramine both increase sedation. cisatracurium and ipratropium both decrease cholinergic effects/transmission. cisatracurium. dichlorphenamide, propofol. Half-life: 5-7 hr; Dialyzable: Yes; Renal clearance: 225 mL/min; 125 mL/min (if older than 70 y) Total body clearance: Proportional to CrCl; Minor/Significance Unknown. Use Caution/Monitor. Risk of apnea. Minor/Significance Unknown. sulfamethoxazole decreases levels of desipramine by unspecified interaction mechanism. The organ-independent nature of the elimination of cisatracurium was characterized by a relationship between steady-state volume of distribution and total body clearance, and the half-life is an independent variable and is not dependent on thetotal body clearance nor the steady- state volume of Distribution. Modify Therapy/Monitor Closely. It is less preferred in low back pain. cisatracurium. clozapine. Effects generally begin within half an hour. conjugated estrogens.
cinnarizine magnesium sulfate increases effects of cisatracurium by pharmacodynamic synergism. Medscape - Hypersensitivity reactions, insomnia, antihistamine-specific dosing for Benadryl, Nytol (diphenhydramine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. cisatracurium and trazodone both decrease cholinergic effects/transmission. St John's Wort will decrease the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sevelamer decreases levels of zonisamide by increasing elimination. cisatracurium. Risk of resp. 1 month of age and low birth-weight infants (contains benzyl alcohol). The elimination rate constant from the peripheral compartment was fixed to the in vitro rate of degradation of cisatracurium in human plasma (0.0237 min (-1)). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. doxycycline increases effects of cisatracurium by pharmacodynamic synergism. cisatracurium decreases levels of droperidol by inhibition of GI absorption. Dialyzable: Hemodialysis, yes; peritoneal dialysis, yes. clozapine Effect of interaction is not clear, use caution. Minor/Significance Unknown. cisatracurium. Avoid or Use Alternate Drug. St John's Wort will decrease the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
cisatracurium and diphenhydramine both decrease cholinergic effects/transmission. Half-life: 2-3 hr (adults); 8.7 hr (premature neonates); 3.6 hr It may be used together with rest, physical therapy, and pain medication. Medscape - Indication-specific dosing for Zyvox (linezolid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Modify Therapy/Monitor Closely. Interaction occurs with parenteral magnesium. Elimination. cisatracurium. scopolamine and clomipramine both decrease cholinergic effects/transmission. tobramycin. Drug interaction overview. Contraindications. Rocuronium, an aminosteroid compound, offers the fastest onset time of all cisatracurium. Avoid concomitant use of inhibitors of the bile salt efflux pump (BSEP). Its exact mechanism of action is not known, but it may be due to general central nervous system depression. Medscape - Hypotension dosing for Intropin (dopamine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. topiramate decreases effects of cisatracurium by pharmacodynamic antagonism. Use Caution/Monitor. Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain.
nicardipine will increase the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism.
Hofmann elimination is an elimination reaction of an amine where the least stable (least substituted) alkene, the Hofmann product, is formed. Cisatracurium Besylate injection should be refrigerated at 2 to 8C (36 to 46F) in the carton to preserve potency. However, there is no report in the literature suggesting that there is a shortening of its activity or quality of action by enhanced metabolism when administered as an infusion via a channel at higher than body temperature. Use Caution/Monitor. clindamycin increases effects of cisatracurium by pharmacodynamic synergism. Avoid concomitant use of inhibitors of the bile salt efflux pump (BSEP). clomipramine. nifedipine increases effects of cisatracurium by pharmacodynamic synergism. Cisatracurium plasma concentration-time data following intravenous bolus administration are best described by a two-compartment open model (with elimination from both compartments) with an elimination half-life (t 1/2 ) of 22 minutes, a plasma clearance (CL) of 4.57 mL/min/kg, and a volume of distribution at steady state (V ss) of 145 mL/kg. Use Caution/Monitor. Extensively metabolized by the liver and plasma elimination half-life is 56 hr in patients with hepatic impairment; titrate slowly when treating patients with severe hepatic impairment. midazolam increases toxicity of cholic acid by decreasing elimination.
cisatracurium. Use Caution/Monitor. Use Caution/Monitor. cisatracurium. sulfamethoxazole, dapsone. Use Caution/Monitor. This tendency, known as the Hofmann alkene synthesis rule, is in contrast to usual elimination reactions, where Zaitsevs rule predicts the formation of the most stable alkene. REPORT ADVERSE EVENTS | Recalls Risk of apnea. cisatracurium. Use Caution/Monitor. gabapentin decreases effects of cisatracurium by pharmacodynamic antagonism. Cautions. Stiripentol is a CYP3A4 inhibitor and inducer. Modify Therapy/Monitor Closely. stiripentol, zonisamide. Half-Life elimination: 2 hr (parent drug), 8-12 hr (metabolites) Onset: 3-10 min. entrectinib. Renal clearance: 0.6 mL/min/kg; 4 mL/min/kg (metabolite) Half-life: 30-120 min (normal renal function); 9 hr (end-stage renal disease) Dialyzable: No. Use Caution/Monitor. Duration: 2-4 hr, may persist up
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